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Omicron’s Early Detection

Monday, 3 January 2022

PCR tests that fail to detect the S gene are the first clues pointing to the Omicron variant. Whole genome sequencing is being prioritized.

A test tube labelled "COVID-19 Test Positive" is seen in front of displayed words "OMICRON SARS-COV-2" in this illustration taken December 11, 2021. REUTERS/Dado Ruvic/Illustration. tempo : 167518346429

MOST laboratories in South Africa—such as the Lancet Laboratories in Johannesburg, which was the first to identify the new SARS-CoV-2 variant, Omicron—apply the reverse transcription-polymerase chain reaction (RT-PCR) technique using reagent kits to evaluate three target genes: S (spike), N (nucleocapsid), and ORF1ab (open reading frame-1ab). Apparently, these tests are able to detect the N and ORF1ab genes, but not the S gene. This c

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